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Kathy fights the devil’s tumours



Kathy is saving the Tassie Devil by identifying the link between genetics and the occurrence of the Devil Facial Tumour Disease

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PCA_belovShe calls herself a ‘dorky natural blonde', but geneticist Dr Kathy Belov is the world's superhero when it comes to fight a hideous contagious cancer that could destroy Australia's wild Tasmanian devils.

"It sounds dorky - but research really is a hobby and a passion of mine," Kathy said.

And it's just as well, because within 25 years, all Tasmanian devils in the wild may die if we don't come up with a way to stop the spread of the contagious cancer, Devil Facial Tumour Disease. Once there were 150,000 devils roaming the island, now there are now less than 50,000.

Kathy and her team of researchers are by far our best hope at saving these marsupials. She worked out that the devils are affected by this cancer because they are essentially clones, sharing the same genes. What's more, she found out that the tumour has similar genes to the devil, which means its immune systems doesn't ‘see' the cancer cells invading and does not attack them.

"One of the main reasons the devils are so likely to get this disease is that their numbers have dropped to very low levels in the past and they have lost their genetic diversity," Kathy said.

"Devils have been through at least three population crashes which were followed by inbreeding - where they have to breed but are quite closely related. So you can end up with more devils, but they all come from a very small gene pool."

Kathy's research showed that the devil's lack of genetic diversity meant that important immune genes that help the body fight infectious disease, called Major Histocompatibility Complex (MHC) genes, also lacked diversity.

Recently, she and her team found some devils in northwestern Tasmania with different MHC genes and put them in a captive breeding program to increase the genetic diversity of captive animals. She is also trying to find out whether some of these animals with different MHC genes can fight the tumour and improve their chances of survival.

"Once genetic diversity is gone, species are not able to respond to disease, and epidemics, such as the one we are seeing in the devil, can take over.

"By carefully selecting the animals we bring in and breed in captivity, we can keep genetic diversity for future release into the wild. If we succeed, this could change how the world conserves threatened species, especially ones that are inbred and live on islands."

Other species that could benefit from Kathy's knowledge are the much loved koalas living on Kangaroo and French Islands and platypuses on King Island.

Science is not just work, for Kathy, it's a joy.

"Science is lots of fun. Many people think of science as being quite isolating - but the best thing about my job is the people. I work with the most inspiring people! My research students are superstars. They work hard, are passionate and so enthusiastic. They make coming into work every day lots of fun."

Kathy entered the UNSW Eureka Prize for Scientific Research.

I believe the DFTD has mutated many times and is now up to mutation 13, is it still possible for the devils in the NW region to be able to recognise all of these cells as foreign, and their immune systems to switch on?

Great question - we are working on it. You may have heard of Cedric. Cedric is a NW devil who is MHC-disparate. He made the news because he successfully mounted an antibody response to a crude vaccine and then did not develop DFTD following challenge.

Since then, Cedric did develop DFTD when he was challenged with a different strain. We don't yet know if it was a strain difference or a lack of vaccination pre challenge that was the key difference.

While I am hopeful some devils may be resistant to the disease, I am also realistic. I think there is going to be strong selection pressure for the tumour to evolve immune evasion strategies.

We need to forge ahead with work on development of vaccines and study of DFTD evolution... however, it is also critical that we focus on the insurance program at the same time.

Katherine, I met other researchers (from CSIRO) working on the 'devils', I think they are based in Geelong. Are you aware / part of this work? Also, here at the Australian Synchrotron we are developing new radiotherapy modalities to treat difficult tumors and I think that pre-clinical trials on selected 'devils' could be a great way to progress as treating 'surface tumors' would be an ideal first step. Are you aware of these new developments? Thanks for your attention. Daniel. (Principal Scientist, Imaging and Medical beamline).

Hi Daniel.

Yes - I am aware of the great work of Alex Hyatt and Linfa Wang! They have hunted for evidence of viruses in DFTD cells and have so far not found any. This helps reinforce the hypothesis that this is an infectious cancer (not a virus).

Greg Woods (UTas), Stephen Pyecroft (DPIW) and David Phalen (USyd) have explored the idea of using chemo on devils. I am not aware of any work on radiation therapies - but I would suggest they be your first points of contact.


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Dr Katherine Belov
University of Sydney, NSW